Question 1

Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of

Accepted Answer

A)  synteny.
B)  exosymbiosis.
C)  endosymbiosis.
D)  draft sequencing of the proteomes of the mitochondria and chloroplasts by the nucleosome.
E)  contiguous base pairing.F) A) and B)
G) C) and E)

Question 2

Why do segmental duplications pose a logistical challenge in the proper alignment of DNA sequences?

Accepted Answer

A)  Segmental duplications are inherently repetitive.
B)  Segmental duplications contain large numbers of LINEs,which interfere with sequence annotation.
C)  Segmental duplications interfere with BLAST analysis.
D)  Segmental duplications are often found in areas of constitutive heterochromatin.E) All of the above
F) None of the above

Question 3

Recombination frequency between genes can used to generate a

Accepted Answer

A)  genetic map.
B)  physical map.
C)  restriction map.
D)  haplotype map.E) A) and B)
F) A) and C)

Question 4

In the early 1980s,a number of clones encoding highly-related forms of actin were isolated from a human cDNA library.Given the information that (i) the restriction enzyme maps of the coding regions were dissimilar,and (ii) each clone contained sufficient coding region to encode all or most of an entire actin gene,you would conclude that

Accepted Answer

A)  multiple actin genes arose as a result of a segmental duplication.
B)  the various forms of actin are a result of alternative splicing.
C)  actin proteins are encoded by genes found in a tandem cluster.
D)  actin proteins are encoded by a multigene family.E) A) and B)
F) B) and C)

Question 5

Following transcription of eukaryotic genes,introns are removed and exons are spliced together.This process is referred to as______.

Accepted Answer

A)  translation
B)  splicing
C)  mRNA modification
D)  couplingE) C) and D)
F) All of the above

Question 6

Which of the following statements regarding pseudogenes is false?

Accepted Answer

A)  Pseudogenes may have some gene-like features such as a promoter and splice sites.
B)  Pseudogenes encode proteins,but the translated proteins are non-functional.
C)  Pseudogenes can provide insight into the evolutionary history of the related functional gene.
D)  Every pseudogene has a similar DNA sequence to some functional gene.E) B) and D)
F) A) and B)

Question 7

A private company has been hired by the parliament of ______ to create a data base from pooled medical,genetic,and genealogical information.

Accepted Answer

A)  Nova Scotia
B)  Iceland
C)  Gibraltar
D)  Portugal
E)  GalapagosF) B) and D)
G) All of the above

Question 8

A pharmaceutical company is trying to develop a new drug to help combat a rare disease.To facilitate the identification of new drug targets,they could

Accepted Answer

A)  search the sequenced human genome for mutations involved in the development of the disease,and design drugs that bind to the mutated proteins.
B)  employ protein microarray technology to evaluate the binding of drugs to various proteins.
C)  test new drugs in transgenic organisms that display disease characteristics.
D)  use antibodies to screen a DNA microarray.E) None of the above
F) B) and C)

Question 9

All of the RNA present in a cell or tissue at a specific time is called the

Accepted Answer

A)  proteome.
B)  spliceosome.
C)  nucleosome.
D)  RNA motif.
E)  transcriptomE.F) B) and D)
G) B) and C)

Question 10

A transgene is an

Accepted Answer

A)  inserted exon.
B)  inserted intron.
C)  inserted nucleosome.
D)  inserted foreign gene.
E)  inserted transcriptomE.F) B) and D)
G) A) and C)

Question 11

A catalog of common genetic variants that occur in humans is called a

Accepted Answer

A)  haplotype map.
B)  restriction map.
C)  genomic map.
D)  SNP map.E) None of the above
F) C) and D)

Question 12

Draft sequences have

Accepted Answer

A)  many gaps in regions of highly repetitive DNA.
B)  less than 1 error in 10,000 nucleotides.
C)  been found in various proteomes across the eukaryote life forms.
D)  been produced by alternative splicing.
E)  several problems,the main one being their contiguous DNA fragments.F) B) and D)
G) A) and B)

Question 13

Your research group has recently determined the complete genomic sequence of the organism Examus biologisium.You instruct your group to begin sequence annotation,which involves

Accepted Answer

A)  shotgun cloning.
B)  the alignment of contigs.
C)  the identification of open reading frames.
D)  the construction of a genetic map.E) All of the above
F) A) and D)

Question 14

Identical copies of genes that can be transcribed simultaneously are called

Accepted Answer

A)  segmental duplications.
B)  pseudogenes.
C)  tandem clusters.
D)  multigene families.
E)  expressed sequences.F) B) and E)
G) A) and E)

Question 15

Given an ideal sequencing reaction of approximately 500 successive nucleotides (excluding overlap) ,how many sequencing reactions would be needed to determine the complete human genome?

Accepted Answer

A)  3.2 billion
B)  12.5 million
C)  12.8 million
D)  6.4 millionE) None of the above
F) B) and C)

Question 16

To avoid confusion,and to allow ease of data interruption,researchers working on cloned DNA from the same species use

Accepted Answer

A)  restriction fragment length polymorphisms.
B)  shotgun sequencing.
C)  sequenced-tagged sites.
D)  clone by clone sequencing.
E)  consensus sequencing.F) A) and B)
G) A) and C)

Question 17

In vertebrates,the family of myogenic regulatory factors (MFRs) plays a major role in muscle development.This family consists of four related genes,including MyoD,MRF4,myogenin,and myf5,each of which have distinct,but overlapping functions.Interestingly,this gene family is represented by only a single gene called nautilus in Drosophila.You want to determine if nautilus functions as the sum of the vertebrate factors,or rather,if it functions in a manner similar to that of one particular gene.Eventually,you plan to examine the loss-of-function phenotype of nautilus mutants.However,first you should

Accepted Answer

A)  compare the DNA and protein sequences of all the genes to determine if nautilus is more closely related to one MRF than another.
B)  perform a DNA microarray to compare gene activation patterns between nautilus and the MRFs.
C)  compare the proteome of a cell expressing nautilus to the proteomes of cells expressing each of the MRFs in turn.
D)  generate four transgenic Drosophila strains that express the MRFs.E) C) and D)
F) All of the above

Question 18

The sequence 5' CGGCGGCGGCGGCGGCGGCGGCGGCGGCGG 3' represents a ______________.

Accepted Answer

A)  fragment
B)  complex sequence
C)  molecule of mRNA
D)  simple sequence repeatE) C) and D)
F) All of the above

Question 19

Conserved arrangements of segments of DNA in related genomes are referred to as

Accepted Answer

A)  synteny.
B)  homology.
C)  analogous DNA.
D)  a contig.
E)  a comparative genomE.F) A) and B)
G) B) and D)

Exam 18: Genomics

Draft sequences have

Correct Answer
verified

A pharmaceutical company is trying to develop a new drug to help combat a rare disease.To facilitate the identification of new drug targets,they could

Correct Answer
verified

To avoid confusion,and to allow ease of data interruption,researchers working on cloned DNA from the same species use

Correct Answer
verified

A transgene is an

Correct Answer
verified

Identical copies of genes that can be transcribed simultaneously are called

Correct Answer
verified

Correct Answer
verified

Given an ideal sequencing reaction of approximately 500 successive nucleotides (excluding overlap) ,how many sequencing reactions would be needed to determine the complete human genome?

Correct Answer
verified

Your research group has recently determined the complete genomic sequence of the organism Examus biologisium.You instruct your group to begin sequence annotation,which involves

Correct Answer
verified

A catalog of common genetic variants that occur in humans is called a

Correct Answer
verified

Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of

Correct Answer
verified

A private company has been hired by the parliament of ______ to create a data base from pooled medical,genetic,and genealogical information.

Correct Answer
verified

All of the RNA present in a cell or tissue at a specific time is called the

Correct Answer
verified

Why do segmental duplications pose a logistical challenge in the proper alignment of DNA sequences?

Correct Answer
verified

Conserved arrangements of segments of DNA in related genomes are referred to as

Correct Answer
verified

Which of the following statements regarding pseudogenes is false?

Correct Answer
verified

Recombination frequency between genes can used to generate a

Correct Answer
verified

Following transcription of eukaryotic genes,introns are removed and exons are spliced together.This process is referred to as______.

Correct Answer
verified

The sequence 5' CGGCGGCGGCGGCGGCGGCGGCGGCGGCGG 3' represents a ______________.

Correct Answer
verified

Correct Answer
verified

Exam 18: Genomics

Draft sequences have

Correct AnswerverifiedShow Answer

A pharmaceutical company is trying to develop a new drug to help combat a rare disease.To facilitate the identification of new drug targets,they could

Correct AnswerverifiedShow Answer

To avoid confusion,and to allow ease of data interruption,researchers working on cloned DNA from the same species use

Correct AnswerverifiedShow Answer

A transgene is an

Correct AnswerverifiedShow Answer

Identical copies of genes that can be transcribed simultaneously are called

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

Given an ideal sequencing reaction of approximately 500 successive nucleotides (excluding overlap) ,how many sequencing reactions would be needed to determine the complete human genome?

Correct AnswerverifiedShow Answer

Your research group has recently determined the complete genomic sequence of the organism Examus biologisium.You instruct your group to begin sequence annotation,which involves

Correct AnswerverifiedShow Answer

A catalog of common genetic variants that occur in humans is called a

Correct AnswerverifiedShow Answer

Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result of

Correct AnswerverifiedShow Answer

A private company has been hired by the parliament of ______ to create a data base from pooled medical,genetic,and genealogical information.

Correct AnswerverifiedShow Answer

All of the RNA present in a cell or tissue at a specific time is called the

Correct AnswerverifiedShow Answer

Why do segmental duplications pose a logistical challenge in the proper alignment of DNA sequences?

Correct AnswerverifiedShow Answer

Conserved arrangements of segments of DNA in related genomes are referred to as

Correct AnswerverifiedShow Answer

Which of the following statements regarding pseudogenes is false?

Correct AnswerverifiedShow Answer

Recombination frequency between genes can used to generate a

Correct AnswerverifiedShow Answer

Following transcription of eukaryotic genes,introns are removed and exons are spliced together.This process is referred to as______.

Correct AnswerverifiedShow Answer

The sequence 5' CGGCGGCGGCGGCGGCGGCGGCGGCGGCGG 3' represents a ______________.

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

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