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During inflammation,a high neutrophil count is a common sign of bacterial infection.

A) True
B) False

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What type of molecules act to draw phagocytes to foreign substances?


A) MALTs
B) RES
C) PAMPs
D) BALTs
E) Lysosomes

F) A) and B)
G) C) and D)

Correct Answer

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C

Plasma ________.


A) is the liquid portion of blood in which blood cells are suspended
B) is mostly water
C) contains albumin and globulins
D) contains fibrinogen
E) All of the choices are correct.

F) A) and D)
G) B) and D)

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Histamine,serotonin,and bradykinin are all ________.


A) vasoactive mediators
B) mediators of B-cell activity
C) mediators of T-cell activity
D) mediators that increase chemotaxis
E) fever inducers

F) C) and D)
G) None of the above

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The body region where a ciliary escalator helps to sweep microbes trapped in mucus away from that body site is the ________.


A) skin
B) respiratory tract
C) digestive tract
D) urinary tract
E) eyes

F) A) and D)
G) B) and E)

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Keratin is an important aspect of nonspecific defense because it ________.


A) is toxic to pathogens
B) creates a physical barrier against pathogens
C) destroys pathogens
D) physically restricts pathogens to a specific region
E) None of the choices are correct.

F) A) and D)
G) A) and C)

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A properly functioning immune system is responsible for ________.


A) surveillance of the body
B) recognition of foreign material
C) destruction of foreign material
D) All of the choices are correct.
E) Only recognition of foreign material and destruction of foreign material are correct.

F) B) and C)
G) A) and B)

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Endotoxin is an exogenous pyrogen.

A) True
B) False

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Cytokines mediate a variety of processes in the immune system,for example,________ encourages inflammatory responses and ________ suppresses the actions of immune cells.


A) TNF-β; IL-10
B) IL-10; TNF-β
C) erythropoietin; TNF-β
D) seratonin; histamine
E) IL-10; IL-7

F) A) and B)
G) D) and E)

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A 16-year-old male with cystic fibrosis is admitted to the inpatient pulmonary unit. He has been hospitalized several times in the past year with respiratory infections, including Pseudomonas and H. influenza. Because of his thick mucous, airway inflammation, and immobile mucosal cilia, microorganisms are unable to be effectively cleared from his lungs. He is supposed to perform vigorous airway mucous clearance measures at home with a vibrating vest and IPV (intrapulmonary percussive ventilation) device. However, the patient states that his treatment takes hours and he does not always feel sick. He estimates his compliance with home airway clearance regimen to be less than 50%. -The patient asks the nurse to explain to him why he keeps getting sick from the same bacteria.Which of the following statements is the most appropriate response? 


A) Your lungs produce these organisms because your cilia are permanently damaged.
B) Your mucus traps and harbors the microorganisms and when they can't be cleared,they begin to breach your second and third lines of defense.
C) Your disease stunts your immunity,so you are unable to fight those bacteria.
D) You don't have second and third line defenses because of your cystic fibrosis.

E) None of the above
F) B) and D)

Correct Answer

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Which of the following is incorrect about circulating blood cells?


A) After birth,produced in red bone marrow sites
B) Develop from undifferentiated stem cells
C) Include Kupffer cells
D) Include leukocytes that are either granulocytes or agranulocytes
E) Include erythrocytes that,when mature,lose their nuclei

F) B) and D)
G) B) and E)

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A 16-year-old male with cystic fibrosis is admitted to the inpatient pulmonary unit. He has been hospitalized several times in the past year with respiratory infections, including Pseudomonas and H. influenza. Because of his thick mucous, airway inflammation, and immobile mucosal cilia, microorganisms are unable to be effectively cleared from his lungs. He is supposed to perform vigorous airway mucous clearance measures at home with a vibrating vest and IPV (intrapulmonary percussive ventilation) device. However, the patient states that his treatment takes hours and he does not always feel sick. He estimates his compliance with home airway clearance regimen to be less than 50%. -If the patient's cilia are unable to clear his lungs of mucus,which line of host defense is breached?


A) First line of defense
B) Second line of defense
C) Third line of defense
D) First and second lines of defense

E) A) and D)
F) A) and C)

Correct Answer

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The second line of defense is a series of systems that involves both cells and chemicals working together.

A) True
B) False

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Which type of white blood cells are particularly attracted to sites of parasitic worm infections?


A) Monocytes
B) Eosinophils
C) Basophils
D) Neutrophils
E) Lymphocytes

F) All of the above
G) A) and E)

Correct Answer

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Which of the following is not a type of phagocyte?


A) Neutrophil
B) Macrophage
C) Kupffer cell
D) Monocyte
E) Lymphocyte

F) A) and B)
G) None of the above

Correct Answer

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E

B lymphocytes and T lymphocytes mature in the thymus gland.

A) True
B) False

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The mother of a 6-year-old child brings her daughter to the pediatrician's office because she has had a sore throat, cough, and fever for several days. She reports a fever up to 104°F that worsens at night, but seems to respond to treatment with acetaminophen. The child has not been eating or drinking well because she says, "it hurts to swallow." She is ill appearing, and does not seem interested in playing with the toys that are in the examination room. The physician notes a thick, white exudate on both of the patient's tonsils, which also seem enlarged. A throat culture and complete blood count with differential is ordered. -The nurse examines the child and finds that the lymph nodes along of her neck are warm,tender,and slightly enlarged.Her other lymph nodes are nonpalpable or small,nontender,rubbery,and less than 2 mm in size.What is the most accurate interpretation of this finding?  


A) This is a normal examination of the posterior cervical chain lymph nodes.
B) This examination is consistent with a systemic infection.
C) This examination is consistent with a localized infection.
D) This examination is definitive for an oncologic diagnosis.

E) None of the above
F) A) and B)

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C

The mother of a 6-year-old child brings her daughter to the pediatrician's office because she has had a sore throat, cough, and fever for several days. She reports a fever up to 104°F that worsens at night, but seems to respond to treatment with acetaminophen. The child has not been eating or drinking well because she says, "it hurts to swallow." She is ill appearing, and does not seem interested in playing with the toys that are in the examination room. The physician notes a thick, white exudate on both of the patient's tonsils, which also seem enlarged. A throat culture and complete blood count with differential is ordered. -The lab performs a complete blood count with cell differential while the patient is still in the office.The results show an elevated white blood cell count,as well as a high neutrophil count.What does this indicate?  


A) Bacterial infection
B) Viral infection
C) Protozoan infection
D) Helminth infection

E) All of the above
F) A) and D)

Correct Answer

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Which of the following is incorrect about inflammation?


A) It can last hours to years.
B) Pyrogens cause vasodilation and increased capillary permeability.
C) Serotonin causes smooth muscle contraction.
D) Fever could be beneficial to inhibiting the pathogen.
E) Basophils and mast cells release histamine.

F) A) and D)
G) A) and E)

Correct Answer

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________ function in humoral immunity,while ________ function in cell-mediated immunity.


A) B cells; T cells
B) T cells; B cells
C) monocytes; basophils
D) basophils; T cells
E) B cells; neutrophils

F) C) and D)
G) B) and C)

Correct Answer

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