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Thioesters are similar to oxygen esters of carboxylic acids except that


A) the energy associated with their hydrolysis is much less than that of the phosphoanhydride in ATP.
B) they are more stable at neutral pH values in cells.
C) they are less stable because S is present instead of O in the linkage.
D) they are used in glycolysis and the citric acid cycle.
E) they are not hydrolyzed enzymatically.

F) A) and D)
G) C) and E)

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When a reduction half-reaction is ________ (negative,positive) ,electrons flow to the more readily reduced substance which is ________ (negative,positive) in value.


A) negative;negative
B) negative;positive
C) positive;positive
D) positive;negative

E) A) and B)
F) C) and D)

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Phosphatases catalyze the hydrolytic removal of phosphate groups.

A) True
B) False

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Fatty acid synthesis occurs in the ________,while fatty acid breakdown occurs in the ________.


A) cytosol;mitochondria
B) cytosol;nucleus
C) mitochondria;cytosol
D) Golgi apparatus;cytosol

E) C) and D)
F) A) and B)

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The ability and capacity of coenzymes to become oxidized or reduced (reduction potential) may be found by


A) measuring the flow of zinc and copper electrons.
B) measuring the flow of electrons when compared to hydrogen gas at standard conditions.
C) measuring the number of H atoms present.
D) All of the above.

E) B) and D)
F) All of the above

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Phosphocreatine and phosphoarginine are ________ that are energy rich phosphate storage molecules found in animal ________ cells.


A) phosphagens;muscle
B) phosphagens;liver
C) plasminogens;muscle
D) plasminogens;liver

E) B) and C)
F) B) and D)

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ATP has the highest possible standard free energy of hydrolysis in cells;therefore it is the most energy-rich compound in living systems.

A) True
B) False

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Bacteria that degrade oil at great depths in offshore waters have most likely evolved new pathways and ________ by modifying existing ones.


A) DNA
B) duplicate factors
C) cofactors
D) enzymes

E) A) and C)
F) A) and B)

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The most biochemically complex organisms are ________.


A) chemoheterotrophs
B) photoheterotrophs
C) heterotrophs
D) autotrophs

E) None of the above
F) A) and C)

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The glycolytic pathway oxidizes glucose to two molecules of pyruvate and also produces a net of two molecules of ATP.ATP allosterically inhibits the enzyme,PFK-1,that catalyzes the third step of glycolysis.This is an example of ________.


A) feed-forward activation
B) feedback inhibition
C) negative cooperativity
D) competitive inhibition

E) C) and D)
F) B) and C)

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Which are membrane-associated pathways?


A) Electron transport chain in eukaryotes.
B) Citric acid cycle in bacteria.
C) Photosynthesis.
D) Glycolysis.
E) Both A and C above.

F) A) and B)
G) A) and E)

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An organism that uses organic molecules as carbon sources and obtains energy by oxidizing inorganic molecules is a(n) ________.


A) photoautotroph
B) chemoautotroph
C) photoheterotroph
D) chemoheterotroph

E) A) and B)
F) A) and C)

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Which compound has a greater free energy of hydrolysis than ATP?


A) Glucose 1-phosphate.
B) Any phosphoester.
C) Phosphoenolpyruvate.
D) Acetyl CoA.
E) All of the above.

F) B) and E)
G) B) and D)

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The chemical energy generated by oxidation reactions cannot be captured by


A) NADH.
B) NADP+.
C) FMN.
D) FAD.
E) Q.

F) A) and C)
G) C) and D)

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The standard potential for electron transfer can be related to the standard free-energy change for redox reactions by using


A) a calorimeter.
B) an electrochemical cell.
C) two solutions separated by a salt bridge.
D) the Nernst equation.
E) the Faraday equation.

F) A) and E)
G) C) and D)

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Most of the fundamental metabolic pathways are present in all species.

A) True
B) False

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Intermediary metabolism is the term applied to reactions that ________.


A) degrade molecules
B) synthesize large molecules such as proteins
C) convert glucose to pyruvate
D) involve low molecular weight metabolites

E) A) and B)
F) A) and C)

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Which is not generally a molecule used to conserve energy?


A) ATP
B) NADH
C) FAD
D) QH²

E) A) and B)
F) All of the above

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In theory at least,the energy released by the oxidation of one molecule of NADH is sufficient to form ________ ATP molecule(s) .


A) 0.5 (meaning it takes about 2 NADH to form 1 ATP)
B) 1
C) several
D) about 20
E) about 50

F) C) and D)
G) A) and B)

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Which statement is false about most metabolic pathways?


A) Most pathways are reversible under physiological conditions.
B) Pathways serve to increase the efficiency of energy transfers.
C) The rates of pathway reactions vary to respond to changing conditions.
D) The enzymes that catalyze reactions in metabolic pathways generally catalyze only a single step.

E) All of the above
F) A) and B)

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